GLDADec: marker-gene guided LDA modeling for bulk gene expression deconvolution
Iori Azuma, Tadahaya Mizuno, Hiroyuki Kusuhara
Briefings in Bioinformatics (2024)
Inferring cell type proportions from bulk transcriptome data is crucial in immunology and oncology. Here, we introduce guided LDA deconvolution (GLDADec), a bulk deconvolution method that guides topics using cell type-specific marker gene names to estimate topic distributions for each sample.
[Paper]