Publication Year | Journal/Book | Title | First Author | Corresponding Author | PMID | Authors | Citation | DOI |
|---|---|---|---|---|---|---|---|---|
| 2025 | J Am Chem Soc | Single-Molecule Oxidoreductase Activity Analysis for Activity-Based Diagnosis Based on Proteoform Alterations | Minoda M | Urano Y, Komatsu T | 39762186 | Minoda M, Hatakeyama J, Nagano N, Mizuno T, Iwasaka T, Shiga S, Takahashi K, Hiraide H, Sakamoto S, Kagami Y, Kashiro A, Honda K, Sugiura Y, Mishima K, Mishima MK, Kusuhara H, Urano Y, Komatsu T. | J Am Chem Soc. 2025 Jan 6. | 10.1021/jacs.4c07624. Online ahead of print. |
| 2025 | Drug Metab Dispos | Development of an OATP1-humanized transchromosomic mouse model for prediction of hepatic drug uptake in humans | Koishikawa T | Kusuhara H | 40023577 | Tomoki Koishikawa, Kanako Kazuki, Rina Ohnishi, Koki Okita, Tadahaya Mizuno, Satoshi Abe, Isamu Nanchi, Yusaku Masago, Kyotaro Yamazaki, Jun-Ichiro Ohzeki, Hiroyuki Kusuhara, Yasuhiro Kazuk | Drug Metab Dispos . 2025 Feb;53(2):100028. | 10.1016/j.dmd.2024.100028. |
| 2025 | Biol Pharm Bull | Development of Research Foundation for Comprehensive Articulation of Drug Effects | Mizuno Tadahaya | Mizuno T | 39756864 | Mizuno Tadahaya | Biol Pharm Bull | 10.1248/bpb.b24-00509 |
| 2024 | Nat Commun | Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators | Kunitake Koki | Kojima R | 39562573 | Kunitake K, Mizuno T, Hattori K, Oneyama C, Kamiya M, Ota S, Urano Y, Kojima R. | . 2025;48(1):1-5. | 10.1038/s41467-024-53736-x.PMID: 39562573 Free PMC article. |
| 2024 | Brief Bioinform | GLDADec: marker-gene guided LDA modeling for bulk gene expression deconvolution | Azuma Iori | Mizuno T | 38982642 | Azuma I, Mizuno T, Kusuhara H. | Brief Bioinform. 2024 May 23;25(4):bbae315. doi: 10.1093/bib/bbae315. | 10.1093/bib/bbae315 |
| 2024 | NAR Genom Bioinform | Investigation of the usefulness of liver-specific deconvolution method by establishing a liver benchmark dataset | Azuma Iori | Mizuno T | 38187088 | Azuma I, Mizuno T, Morita K, Suzuki Y, Kusuhara H. | NAR Genom Bioinform. 2024 Jan 5;6(1):lqad111. doi: 10.1093/nargab/lqad111. eCollection 2024 Mar. | 10.1093/nargab/lqad111 |
| 2024 | Adv Sci (Weinh) | Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition | Ukegawa Tatsuya | Komatsu T | 38140707 | Ukegawa T, Komatsu T, Minoda M, Matsumoto T, Iwasaka T, Mizuno T, Tachibana R, Sakamoto S, Hanaoka K, Kusuhara H, Honda K, Watanabe R, Urano Y. | Adv Sci (Weinh). 2024 Mar;11(10):e2306559. doi: 10.1002/advs.202306559. Epub 2023 Dec 22. | 10.1002/advs.202306559 |
| 2024 | Nat Commun | Difficulty in chirality recognition for Transformer architectures learning chemical structures from string representations | Yoshikai Yasuhiro | Mizuno T | 38365821 | Yoshikai Y, Mizuno T, Nemoto S, Kusuhara H. | Nat Commun. 2024 Feb 16;15(1):1197. doi: 10.1038/s41467-024-45102-8. | 10.1038/s41467-024-45102-8 |
| 2024 | Orphanet J Rare Dis | Clinical symptoms, biochemistry, and liver histology during the native liver period of progressive familial intrahepatic cholestasis type 2 | Kondou Hiroki | Hayashi H | 38341604 | Kondou H, Nakano S, Mizuno T, Bessho K, Hasegawa Y, Nakazawa A, Tanikawa K, Azuma Y, Okamoto T, Inui A, Imagawa K, Kasahara M, Zen Y, Suzuki M, Hayashi H. | Orphanet J Rare Dis. 2024 Feb 10;19(1):57. doi: 10.1186/s13023-024-03080-6. | 10.1186/s13023-024-03080-6 |
| 2024 | Cell Rep Methods | Identification of activity-based biomarkers for early-stage pancreatic tumors in blood using single-molecule enzyme activity screening | Sakamoto Shingo | Urano Y, Komatsu T | 38218189 | Sakamoto S, Hiraide H, Minoda M, Iwakura N, Suzuki M, Ando J, Takahashi C, Takahashi I, Murai K, Kagami Y, Mizuno T, Koike T, Nara S, Morizane C, Hijioka S, Kashiro A, Honda K, Watanabe R, Urano Y, Komatsu T. | Cell Rep Methods. 2024 Jan 22;4(1):100688. doi: 10.1016/j.crmeth.2023.100688. Epub 2024 Jan 12. | 10.1016/j.crmeth.2023.100688 |
| 2024 | J Toxicol Sci | Investigation of normalization procedures for transcriptome profiles of compounds oriented toward practical study design | Mizuno Tadahaya | Mizuno T | 38825484 | Mizuno T, Kusuhara H. | J Toxicol Sci. 2024;49(6):249-259. doi: 10.2131/jts.49.249. | 10.2131/jts.49.249 |
| 2024 | Comput Biol Med | Investigation of latent representation of toxicopathological images extracted by CNN model for understanding compound properties in vivo | Maedera Shotaro | Mizuno T | 38016375 | Maedera S, Mizuno T, Kusuhara H. | Comput Biol Med. 2024 Jan;168:107748. doi: 10.1016/j.compbiomed.2023.107748. Epub 2023 Nov 23. | 10.1016/j.compbiomed.2023.107748 |
| 2023 | Nat Commun | Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis | Tamura Ryutaro | Hayashi H | 37990006 | Tamura R, Sabu Y, Mizuno T, Mizuno S, Nakano S, Suzuki M, Abukawa D, Kaji S, Azuma Y, Inui A, Okamoto T, Shimizu S, Fukuda A, Sakamoto S, Kasahara M, Takahashi S, Kusuhara H, Zen Y, Ando T, Hayashi H. | Nat Commun. 2023 Nov 21;14(1):6763. doi: 10.1038/s41467-023-42424-x. | 10.1038/s41467-023-42424-x |
| 2023 | Toxicol Sci | Rat Deconvolution as Knowledge Miner for Immune Cell Trafficking from Toxicogenomics Databases | Morita Katsuhisa | Mizuno T | 37941435 | Morita K, Mizuno T, Azuma I, Suzuki Y, Kusuhara H. | Toxicol Sci. 2023 Nov 6;197(2):121-31. doi: 10.1093/toxsci/kfad117. Online ahead of print. | 10.1093/toxsci/kfad117 |
| 2023 | J Cheminform | Investigation of chemical structure recognition by encoder-decoder models in learning progress | Nemoto Shumpei | Mizuno T | 37046349 | Nemoto S, Mizuno T, Kusuhara H. | J Cheminform. 2023 Apr 12;15(1):45. doi: 10.1186/s13321-023-00713-z. | 10.1186/s13321-023-00713-z |
| 2023 | NAR Genom Bioinform | Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method | Ishiguro Hiromu | Mizuno T,Uchida Y, Kusuhara H | 36915410 | Ishiguro H, Mizuno T, Uchida Y, Sato R, Sasaki H, Nemoto S, Terasaki T, Kusuhara H. | NAR Genom Bioinform. 2023 Mar 11;5(1):lqad022. doi: 10.1093/nargab/lqad022. eCollection 2023 Mar. | 10.1093/nargab/lqad022 |
| 2023 | J Chem Inf Model | NRBdMF: A Recommendation Algorithm for Predicting Drug Effects Considering Directionality | Azuma Iori | Mizuno T | 36635231 | Azuma I, Mizuno T, Kusuhara H. | J Chem Inf Model. 2023 Jan 23;63(2):474-483. doi: 10.1021/acs.jcim.2c01210. Epub 2023 Jan 12. | 10.1021/acs.jcim.2c01210 |
| 2023 | Yakugaku Zasshi | [Understanding of Multiple Effects of Low Molecular Weight Compounds with Factor Analysis] | Mizuno Tadahaya | Mizuno T | 36724926 | Mizuno T, Nemoto S, Morita K, Kusuhara H. | Yakugaku Zasshi. 2023;143(2):127-132. doi: 10.1248/yakushi.22-00156-2. | 10.1248/yakushi.22-00156-2 |
| 2022 | J Chem Inf Model | Investigation of a Data Split Strategy Involving the Time Axis in Adverse Event Prediction Using Machine Learning | Morita Katsuhisa | Mizuno T | 35971760 | Morita K, Mizuno T, Kusuhara H. | J Chem Inf Model. 2022 Sep 12;62(17):3982-3992. doi: 10.1021/acs.jcim.2c00765. Epub 2022 Aug 16. | 10.1021/acs.jcim.2c00765 |
| 2022 | Clin Pharmacol Ther | Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions | Mochizuki Tatsuki | Kusuhara H | 35292967 | Mochizuki T, Zamek-Gliszczynski MJ, Yoshida K, Mao J, Taskar K, Hirabayashi H, Chu X, Lai Y, Takashima T, Rockich K, Yamaura Y, Fujiwara K, Mizuno T, Maeda K, Furihata K, Sugiyama Y, Kusuhara H. | Clin Pharmacol Ther. 2022 Jun;111(6):1315-1323. doi: 10.1002/cpt.2584. Epub 2022 Apr 11. | 10.1002/cpt.2584 |
| 2022 | Yakugaku Zasshi | [Development of Decomposition Approach for Comprehensive Understanding of Drug Effects] | Mizuno Tadahaya | Mizuno T | 36184442 | Mizuno T. | Yakugaku Zasshi. 2022;142(10):1077-1082. doi: 10.1248/yakushi.22-00123. | 10.1248/yakushi.22-00123 |
| 2021 | Mol Genet Metab Rep | Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders | Nakajima Yoko | Hayashi H | 34522617 | Nakajima Y, Osaka S, Mizuno T, Yokoi K, Nakano S, Hirai S, Hiraoka Y, Miura Y, Suzuki M, Kusuhara H, Hayashi H. | Mol Genet Metab Rep. 2021 Sep 4;29:100799. doi: 10.1016/j.ymgmr.2021.100799. eCollection 2021 Dec. | 10.1016/j.ymgmr.2021.100799 |
| 2021 | J Nat Prod | Decomposition Profile Data Analysis for Deep Understanding of Multiple Effects of Natural Products | Nemoto Shumpei | Mizuno T | 33836128 | Nemoto S, Morita K, Mizuno T, Kusuhara H. | J Nat Prod. 2021 Apr 23;84(4):1283-1293. doi: 10.1021/acs.jnatprod.0c01381. Epub 2021 Apr 9. | 10.1021/acs.jnatprod.0c01381 |
| 2021 | Mol Genet Metab | A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers | Osaka Shuhei | Hayashi H | 33648834 | Osaka S, Nakano S, Mizuno T, Hiraoka Y, Minowa K, Hirai S, Mizutani A, Sabu Y, Miura Y, Shimizu T, Kusuhara H, Suzuki M, Hayashi H. | Mol Genet Metab. 2021 Apr;132(4):220-226. doi: 10.1016/j.ymgme.2021.02.002. Epub 2021 Feb 23. | 10.1016/j.ymgme.2021.02.002 |
| 2021 | Drug Metab Pharmacokinet | Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development | Mochizuki Tatsuki | Kusuhara H | 33461054 | Mochizuki T, Mizuno T, Maeda K, Kusuhara H. | Drug Metab Pharmacokinet. 2021 Apr;37:100358. doi: 10.1016/j.dmpk.2020.09.003. Epub 2020 Sep 22. | 10.1016/j.dmpk.2020.09.003 |
| 2021 | Drug Metab Dispos | Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier | Mochizuki Tatsuki | Kusuhara H | 33144341 | Mochizuki T, Mizuno T, Kurosawa T, Yamaguchi T, Higuchi K, Tega Y, Nozaki Y, Kawabata K, Deguchi Y, Kusuhara H. | Drug Metab Dispos. 2021 Jan;49(1):3-11. doi: 10.1124/dmd.120.000115. Epub 2020 Nov 3. | 10.1124/dmd.120.000115 |
| 2020 | Sci Rep | Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor | Morita Katsuhisa | Mizuno T | 32753643 | Morita K, Mizuno T, Kusuhara H. | Sci Rep. 2020 Aug 4;10(1):13139. doi: 10.1038/s41598-020-70140-9. | 10.1038/s41598-020-70140-9 |
| 2020 | Drug Metab Dispos | Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel | Mori Daiki | Kusuhara H | 32114508 | Mori D, Ishida H, Mizuno T, Kusumoto S, Kondo Y, Izumi S, Nakata G, Nozaki Y, Maeda K, Sasaki Y, Fujita KI, Kusuhara H. | Drug Metab Dispos. 2020 May;48(5):387-394. doi: 10.1124/dmd.119.089474. Epub 2020 Feb 29. | 10.1124/dmd.119.089474 |
| 2020 | Biol Pharm Bull | Interesting Properties of Profile Data Analysis in the Understanding and Utilization of the Effects of Drugs | Mizuno Tadahaya | Mizuno T | 32999153 | Mizuno T, Morita K, Kusuhara H. | Biol Pharm Bull. 2020;43(10):1435-1442. doi: 10.1248/bpb.b20-00301. | 10.1248/bpb.b20-00301 |
| 2019 | Drug Metab Dispos | Elucidation of N (1)-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters | Miyake Takeshi | Kusuhara H | 31511257 | Miyake T, Mizuno T, Takehara I, Mochizuki T, Kimura M, Matsuki S, Irie S, Watanabe N, Kato Y, Ieiri I, Maeda K, Ando O, Kusuhara H. | Drug Metab Dispos. 2019 Nov;47(11):1270-1280. doi: 10.1124/dmd.119.087262. Epub 2019 Sep 11. | 10.1124/dmd.119.087262 |
| 2019 | Sci Rep | Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components | Mizuno Tadahaya | Mizuno T | 30755704 | Mizuno T, Kinoshita S, Ito T, Maedera S, Kusuhara H. | Sci Rep. 2019 Feb 12;9(1):1824. doi: 10.1038/s41598-019-38528-4. | 10.1038/s41598-019-38528-4 |
| 2019 | Drug Metab Pharmacokinet | Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney | Kito Tomoko | Kusuhara H | 30528339 | Kito T, Ito S, Mizuno T, Maeda K, Kusuhara H. | Drug Metab Pharmacokinet. 2019 Feb;34(1):87-94. doi: 10.1016/j.dmpk.2018.08.005. Epub 2018 Sep 20. | 10.1016/j.dmpk.2018.08.005 |
| 2019 | Biol Pharm Bull | Development of a Novel Platform of Proteome Profiling Based on an Easy-to-Handle and Informative 2D-DIGE System | Kinoshita Setsuo | Mizuno T | 31787721 | Kinoshita S, Mizuno T, Hori M, Kohno M, Kusuhara H. | Biol Pharm Bull. 2019;42(12):2069-2075. doi: 10.1248/bpb.b19-00571. | 10.1248/bpb.b19-00571 |
| 2019 | FEBS Lett | GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages | Maedera Shotaro | Mizuno T | 30431159 | Maedera S, Mizuno T, Ishiguro H, Ito T, Soga T, Kusuhara H. | FEBS Lett. 2019 Jan;593(2):195-208. doi: 10.1002/1873-3468.13298. Epub 2018 Dec 4. | 10.1002/1873-3468.13298 |
| 2018 | Drug Metab Dispos | Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier | Sano Yamato | Kusuhara H | 30154106 | Sano Y, Mizuno T, Mochizuki T, Uchida Y, Umetsu M, Terasaki T, Kusuhara H. | Drug Metab Dispos. 2018 Nov;46(11):1767-1775. doi: 10.1124/dmd.118.081877. Epub 2018 Aug 28. | 10.1124/dmd.118.081877 |
| 2018 | Sci Rep | Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo | Kuwahara Hiroya | Yokota T | 29531265 | Kuwahara H, Song J, Shimoura T, Yoshida-Tanaka K, Mizuno T, Mochizuki T, Zeniya S, Li F, Nishina K, Nagata T, Ito S, Kusuhara H, Yokota T. | Sci Rep. 2018 Mar 12;8(1):4377. doi: 10.1038/s41598-018-22577-2. | 10.1038/s41598-018-22577-2 |
| 2017 | J Pharm Sci | Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide | Miyake Takeshi | Kusuhara H | 28479364 | Miyake T, Mizuno T, Mochizuki T, Kimura M, Matsuki S, Irie S, Ieiri I, Maeda K, Kusuhara H. | J Pharm Sci. 2017 Sep;106(9):2542-2550. doi: 10.1016/j.xphs.2017.04.067. Epub 2017 May 4. | 10.1016/j.xphs.2017.04.067 |
| 2015 | Arterioscler Thromb Vasc Biol | Cellular Cholesterol Accumulation Facilitates Ubiquitination and Lysosomal Degradation of Cell Surface-Resident ABCA1 | Mizuno Tadahaya | Hayashi H | 25838426 | Mizuno T, Hayashi H, Kusuhara H. | Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1347-56. doi: 10.1161/ATVBAHA.114.305182. Epub 2015 Apr 2. | 10.1161/ATVBAHA.114.305182 |
| 2014 | Mol Pharmacol | Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2 | Aida Kensuke | Hayashi H | 24378332 | Aida K, Hayashi H, Inamura K, Mizuno T, Sugiyama Y. | Mol Pharmacol. 2014 Mar;85(3):482-91. doi: 10.1124/mol.113.091090. Epub 2013 Dec 30. | 10.1124/mol.113.091090 |
| 2012 | J Hepatol | 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration | Hayashi Hisamitsu | Hayashi H,Sugiyama Y | 22245901 | Hayashi H, Mizuno T, Horikawa R, Nagasaka H, Yabuki T, Takikawa H, Sugiyama Y. | J Hepatol. 2012 May;56(5):1136-1144. doi: 10.1016/j.jhep.2011.11.021. Epub 2012 Jan 13. | 10.1016/j.jhep.2011.11.021 |
| 2011 | Hepatology | Ubiquitination is associated with lysosomal degradation of cell surface-resident ATP-binding cassette transporter A1 (ABCA1) through the endosomal sorting complex required for transport (ESCRT) pathway | Mizuno Tadahaya | Hayashi H | 21520210 | Mizuno T, Hayashi H, Naoi S, Sugiyama Y. | Hepatology. 2011 Aug;54(2):631-43. doi: 10.1002/hep.24387. Epub 2011 Jun 26. | 10.1002/hep.24387 |