Publication Year | PMID | Title | Authors | Citation | First Author | Journal/Book | DOI | |
|---|---|---|---|---|---|---|---|---|
| 2024 | 38982642 | GLDADec: marker-gene guided LDA modeling for bulk gene expression deconvolution | Azuma I, Mizuno T, Kusuhara H. | Brief Bioinform. 2024 May 23;25(4):bbae315. doi: 10.1093/bib/bbae315. | Azuma I | Brief Bioinform | 10.1093/bib/bbae315 | |
| 2024 | 38187088 | Investigation of the usefulness of liver-specific deconvolution method by establishing a liver benchmark dataset | Azuma I, Mizuno T, Morita K, Suzuki Y, Kusuhara H. | NAR Genom Bioinform. 2024 Jan 5;6(1):lqad111. doi: 10.1093/nargab/lqad111. eCollection 2024 Mar. | Azuma I | NAR Genom Bioinform | 10.1093/nargab/lqad111 | |
| 2024 | 38140707 | Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition | Ukegawa T, Komatsu T, Minoda M, Matsumoto T, Iwasaka T, Mizuno T, Tachibana R, Sakamoto S, Hanaoka K, Kusuhara H, Honda K, Watanabe R, Urano Y. | Adv Sci (Weinh). 2024 Mar;11(10):e2306559. doi: 10.1002/advs.202306559. Epub 2023 Dec 22. | Ukegawa T | Adv Sci (Weinh) | 10.1002/advs.202306559 | |
| 2024 | 38365821 | Difficulty in chirality recognition for Transformer architectures learning chemical structures from string representations | Yoshikai Y, Mizuno T, Nemoto S, Kusuhara H. | Nat Commun. 2024 Feb 16;15(1):1197. doi: 10.1038/s41467-024-45102-8. | Yoshikai Y | Nat Commun | 10.1038/s41467-024-45102-8 | |
| 2024 | 38341604 | Clinical symptoms, biochemistry, and liver histology during the native liver period of progressive familial intrahepatic cholestasis type 2 | Kondou H, Nakano S, Mizuno T, Bessho K, Hasegawa Y, Nakazawa A, Tanikawa K, Azuma Y, Okamoto T, Inui A, Imagawa K, Kasahara M, Zen Y, Suzuki M, Hayashi H. | Orphanet J Rare Dis. 2024 Feb 10;19(1):57. doi: 10.1186/s13023-024-03080-6. | Kondou H | Orphanet J Rare Dis | 10.1186/s13023-024-03080-6 | |
| 2024 | 38218189 | Identification of activity-based biomarkers for early-stage pancreatic tumors in blood using single-molecule enzyme activity screening | Sakamoto S, Hiraide H, Minoda M, Iwakura N, Suzuki M, Ando J, Takahashi C, Takahashi I, Murai K, Kagami Y, Mizuno T, Koike T, Nara S, Morizane C, Hijioka S, Kashiro A, Honda K, Watanabe R, Urano Y, Komatsu T. | Cell Rep Methods. 2024 Jan 22;4(1):100688. doi: 10.1016/j.crmeth.2023.100688. Epub 2024 Jan 12. | Sakamoto S | Cell Rep Methods | 10.1016/j.crmeth.2023.100688 | |
| 2024 | 38825484 | Investigation of normalization procedures for transcriptome profiles of compounds oriented toward practical study design | Mizuno T, Kusuhara H. | J Toxicol Sci. 2024;49(6):249-259. doi: 10.2131/jts.49.249. | Mizuno T | J Toxicol Sci | 10.2131/jts.49.249 | |
| 2024 | 38016375 | Investigation of latent representation of toxicopathological images extracted by CNN model for understanding compound properties in vivo | Maedera S, Mizuno T, Kusuhara H. | Comput Biol Med. 2024 Jan;168:107748. doi: 10.1016/j.compbiomed.2023.107748. Epub 2023 Nov 23. | Maedera S | Comput Biol Med | 10.1016/j.compbiomed.2023.107748 | |
| 2023 | 37990006 | Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis | Tamura R, Sabu Y, Mizuno T, Mizuno S, Nakano S, Suzuki M, Abukawa D, Kaji S, Azuma Y, Inui A, Okamoto T, Shimizu S, Fukuda A, Sakamoto S, Kasahara M, Takahashi S, Kusuhara H, Zen Y, Ando T, Hayashi H. | Nat Commun. 2023 Nov 21;14(1):6763. doi: 10.1038/s41467-023-42424-x. | Tamura R | Nat Commun | 10.1038/s41467-023-42424-x | |
| 2023 | 37941435 | Rat Deconvolution as Knowledge Miner for Immune Cell Trafficking from Toxicogenomics Databases | Morita K, Mizuno T, Azuma I, Suzuki Y, Kusuhara H. | Toxicol Sci. 2023 Nov 6;197(2):121-31. doi: 10.1093/toxsci/kfad117. Online ahead of print. | Morita K | Toxicol Sci | 10.1093/toxsci/kfad117 | |
| 2023 | 37046349 | Investigation of chemical structure recognition by encoder-decoder models in learning progress | Nemoto S, Mizuno T, Kusuhara H. | J Cheminform. 2023 Apr 12;15(1):45. doi: 10.1186/s13321-023-00713-z. | Nemoto S | J Cheminform | 10.1186/s13321-023-00713-z | |
| 2023 | 36915410 | Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method | Ishiguro H, Mizuno T, Uchida Y, Sato R, Sasaki H, Nemoto S, Terasaki T, Kusuhara H. | NAR Genom Bioinform. 2023 Mar 11;5(1):lqad022. doi: 10.1093/nargab/lqad022. eCollection 2023 Mar. | Ishiguro H | NAR Genom Bioinform | 10.1093/nargab/lqad022 | |
| 2023 | 36635231 | NRBdMF: A Recommendation Algorithm for Predicting Drug Effects Considering Directionality | Azuma I, Mizuno T, Kusuhara H. | J Chem Inf Model. 2023 Jan 23;63(2):474-483. doi: 10.1021/acs.jcim.2c01210. Epub 2023 Jan 12. | Azuma I | J Chem Inf Model | 10.1021/acs.jcim.2c01210 | |
| 2023 | 36724926 | [Understanding of Multiple Effects of Low Molecular Weight Compounds with Factor Analysis] | Mizuno T, Nemoto S, Morita K, Kusuhara H. | Yakugaku Zasshi. 2023;143(2):127-132. doi: 10.1248/yakushi.22-00156-2. | Mizuno T | Yakugaku Zasshi | 10.1248/yakushi.22-00156-2 | |
| 2022 | 35971760 | Investigation of a Data Split Strategy Involving the Time Axis in Adverse Event Prediction Using Machine Learning | Morita K, Mizuno T, Kusuhara H. | J Chem Inf Model. 2022 Sep 12;62(17):3982-3992. doi: 10.1021/acs.jcim.2c00765. Epub 2022 Aug 16. | Morita K | J Chem Inf Model | 10.1021/acs.jcim.2c00765 | |
| 2022 | 35292967 | Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions | Mochizuki T, Zamek-Gliszczynski MJ, Yoshida K, Mao J, Taskar K, Hirabayashi H, Chu X, Lai Y, Takashima T, Rockich K, Yamaura Y, Fujiwara K, Mizuno T, Maeda K, Furihata K, Sugiyama Y, Kusuhara H. | Clin Pharmacol Ther. 2022 Jun;111(6):1315-1323. doi: 10.1002/cpt.2584. Epub 2022 Apr 11. | Mochizuki T | Clin Pharmacol Ther | 10.1002/cpt.2584 | |
| 2022 | 36184442 | [Development of Decomposition Approach for Comprehensive Understanding of Drug Effects] | Mizuno T. | Yakugaku Zasshi. 2022;142(10):1077-1082. doi: 10.1248/yakushi.22-00123. | Mizuno T | Yakugaku Zasshi | 10.1248/yakushi.22-00123 | |
| 2021 | 34522617 | Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders | Nakajima Y, Osaka S, Mizuno T, Yokoi K, Nakano S, Hirai S, Hiraoka Y, Miura Y, Suzuki M, Kusuhara H, Hayashi H. | Mol Genet Metab Rep. 2021 Sep 4;29:100799. doi: 10.1016/j.ymgmr.2021.100799. eCollection 2021 Dec. | Nakajima Y | Mol Genet Metab Rep | 10.1016/j.ymgmr.2021.100799 | |
| 2021 | 33836128 | Decomposition Profile Data Analysis for Deep Understanding of Multiple Effects of Natural Products | Nemoto S, Morita K, Mizuno T, Kusuhara H. | J Nat Prod. 2021 Apr 23;84(4):1283-1293. doi: 10.1021/acs.jnatprod.0c01381. Epub 2021 Apr 9. | Nemoto S | J Nat Prod | 10.1021/acs.jnatprod.0c01381 | |
| 2021 | 33648834 | A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers | Osaka S, Nakano S, Mizuno T, Hiraoka Y, Minowa K, Hirai S, Mizutani A, Sabu Y, Miura Y, Shimizu T, Kusuhara H, Suzuki M, Hayashi H. | Mol Genet Metab. 2021 Apr;132(4):220-226. doi: 10.1016/j.ymgme.2021.02.002. Epub 2021 Feb 23. | Osaka S | Mol Genet Metab | 10.1016/j.ymgme.2021.02.002 | |
| 2021 | 33461054 | Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development | Mochizuki T, Mizuno T, Maeda K, Kusuhara H. | Drug Metab Pharmacokinet. 2021 Apr;37:100358. doi: 10.1016/j.dmpk.2020.09.003. Epub 2020 Sep 22. | Mochizuki T | Drug Metab Pharmacokinet | 10.1016/j.dmpk.2020.09.003 | |
| 2021 | 33144341 | Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier | Mochizuki T, Mizuno T, Kurosawa T, Yamaguchi T, Higuchi K, Tega Y, Nozaki Y, Kawabata K, Deguchi Y, Kusuhara H. | Drug Metab Dispos. 2021 Jan;49(1):3-11. doi: 10.1124/dmd.120.000115. Epub 2020 Nov 3. | Mochizuki T | Drug Metab Dispos | 10.1124/dmd.120.000115 | |
| 2020 | 32753643 | Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor | Morita K, Mizuno T, Kusuhara H. | Sci Rep. 2020 Aug 4;10(1):13139. doi: 10.1038/s41598-020-70140-9. | Morita K | Sci Rep | 10.1038/s41598-020-70140-9 | |
| 2020 | 32114508 | Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel | Mori D, Ishida H, Mizuno T, Kusumoto S, Kondo Y, Izumi S, Nakata G, Nozaki Y, Maeda K, Sasaki Y, Fujita KI, Kusuhara H. | Drug Metab Dispos. 2020 May;48(5):387-394. doi: 10.1124/dmd.119.089474. Epub 2020 Feb 29. | Mori D | Drug Metab Dispos | 10.1124/dmd.119.089474 | |
| 2020 | 32999153 | Interesting Properties of Profile Data Analysis in the Understanding and Utilization of the Effects of Drugs | Mizuno T, Morita K, Kusuhara H. | Biol Pharm Bull. 2020;43(10):1435-1442. doi: 10.1248/bpb.b20-00301. | Mizuno T | Biol Pharm Bull | 10.1248/bpb.b20-00301 | |
| 2019 | 31511257 | Elucidation of N (1)-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters | Miyake T, Mizuno T, Takehara I, Mochizuki T, Kimura M, Matsuki S, Irie S, Watanabe N, Kato Y, Ieiri I, Maeda K, Ando O, Kusuhara H. | Drug Metab Dispos. 2019 Nov;47(11):1270-1280. doi: 10.1124/dmd.119.087262. Epub 2019 Sep 11. | Miyake T | Drug Metab Dispos | 10.1124/dmd.119.087262 | |
| 2019 | 30755704 | Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components | Mizuno T, Kinoshita S, Ito T, Maedera S, Kusuhara H. | Sci Rep. 2019 Feb 12;9(1):1824. doi: 10.1038/s41598-019-38528-4. | Mizuno T | Sci Rep | 10.1038/s41598-019-38528-4 | |
| 2019 | 30528339 | Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney | Kito T, Ito S, Mizuno T, Maeda K, Kusuhara H. | Drug Metab Pharmacokinet. 2019 Feb;34(1):87-94. doi: 10.1016/j.dmpk.2018.08.005. Epub 2018 Sep 20. | Kito T | Drug Metab Pharmacokinet | 10.1016/j.dmpk.2018.08.005 | |
| 2019 | 31787721 | Development of a Novel Platform of Proteome Profiling Based on an Easy-to-Handle and Informative 2D-DIGE System | Kinoshita S, Mizuno T, Hori M, Kohno M, Kusuhara H. | Biol Pharm Bull. 2019;42(12):2069-2075. doi: 10.1248/bpb.b19-00571. | Kinoshita S | Biol Pharm Bull | 10.1248/bpb.b19-00571 | |
| 2019 | 30431159 | GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages | Maedera S, Mizuno T, Ishiguro H, Ito T, Soga T, Kusuhara H. | FEBS Lett. 2019 Jan;593(2):195-208. doi: 10.1002/1873-3468.13298. Epub 2018 Dec 4. | Maedera S | FEBS Lett | 10.1002/1873-3468.13298 | |
| 2018 | 30154106 | Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier | Sano Y, Mizuno T, Mochizuki T, Uchida Y, Umetsu M, Terasaki T, Kusuhara H. | Drug Metab Dispos. 2018 Nov;46(11):1767-1775. doi: 10.1124/dmd.118.081877. Epub 2018 Aug 28. | Sano Y | Drug Metab Dispos | 10.1124/dmd.118.081877 | |
| 2018 | 29531265 | Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo | Kuwahara H, Song J, Shimoura T, Yoshida-Tanaka K, Mizuno T, Mochizuki T, Zeniya S, Li F, Nishina K, Nagata T, Ito S, Kusuhara H, Yokota T. | Sci Rep. 2018 Mar 12;8(1):4377. doi: 10.1038/s41598-018-22577-2. | Kuwahara H | Sci Rep | 10.1038/s41598-018-22577-2 | |
| 2017 | 28479364 | Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide | Miyake T, Mizuno T, Mochizuki T, Kimura M, Matsuki S, Irie S, Ieiri I, Maeda K, Kusuhara H. | J Pharm Sci. 2017 Sep;106(9):2542-2550. doi: 10.1016/j.xphs.2017.04.067. Epub 2017 May 4. | Miyake T | J Pharm Sci | 10.1016/j.xphs.2017.04.067 | |
| 2015 | 25838426 | Cellular Cholesterol Accumulation Facilitates Ubiquitination and Lysosomal Degradation of Cell Surface-Resident ABCA1 | Mizuno T, Hayashi H, Kusuhara H. | Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1347-56. doi: 10.1161/ATVBAHA.114.305182. Epub 2015 Apr 2. | Mizuno T | Arterioscler Thromb Vasc Biol | 10.1161/ATVBAHA.114.305182 | |
| 2014 | 24378332 | Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2 | Aida K, Hayashi H, Inamura K, Mizuno T, Sugiyama Y. | Mol Pharmacol. 2014 Mar;85(3):482-91. doi: 10.1124/mol.113.091090. Epub 2013 Dec 30. | Aida K | Mol Pharmacol | 10.1124/mol.113.091090 | |
| 2012 | 22245901 | 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration | Hayashi H, Mizuno T, Horikawa R, Nagasaka H, Yabuki T, Takikawa H, Sugiyama Y. | J Hepatol. 2012 May;56(5):1136-1144. doi: 10.1016/j.jhep.2011.11.021. Epub 2012 Jan 13. | Hayashi H | J Hepatol | 10.1016/j.jhep.2011.11.021 | |
| 2011 | 21520210 | Ubiquitination is associated with lysosomal degradation of cell surface-resident ATP-binding cassette transporter A1 (ABCA1) through the endosomal sorting complex required for transport (ESCRT) pathway | Mizuno T, Hayashi H, Naoi S, Sugiyama Y. | Hepatology. 2011 Aug;54(2):631-43. doi: 10.1002/hep.24387. Epub 2011 Jun 26. | Mizuno T | Hepatology | 10.1002/hep.24387 |
